In a medium mixing bowl, combine the chicken tenders and buttermilk. Cover and refrigerate for at least 30 minutes, preferably up to 2 hours.
Preheat your oven to 400°F (200°C) and line a baking sheet with parchment paper. In a shallow dish, whisk together the flour, garlic powder, onion powder, smoked paprika, salt, black pepper, and cayenne pepper. In another dish, pour in the breadcrumbs.
Remove the marinated chicken tenders from the refrigerator. Allow excess buttermilk to drip off, then dip each tender into the flour mixture, coating thoroughly. Shake off excess flour and transfer to the breadcrumb mixture, pressing gently to adhere.
Arrange the coated chicken tenders on the prepared baking sheet in a single layer. Lightly spray with cooking spray or drizzle with olive oil.
Bake for 15-20 minutes or until golden brown and internal temperature reaches 165°F (74°C), flipping halfway through for even cooking.
Remove from the oven and let rest for 3-5 minutes before serving. Enjoy with dipping sauces like honey mustard, barbecue, or creamy ranch.
Notes
For extra crunch, use panko breadcrumbs. Adjust cayenne pepper to taste for heat.